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Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
Published on: June 14, 2024
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Colchicine Myopathy: A Case Series Including Muscle MRI and ABCB1 Polymorphism Data
Mehul Gupta1, Ana Nikolic2, Denise Ng2
1Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Frontiers in Neurology
|June 11, 2019
Summary
Colchicine myopathy is a rare side effect. Genetic analysis suggests reduced ABCB1 gene activity may increase risk, especially when combined with statins.
Area of Science:
- Pharmacogenomics
- Neurology
- Toxicology
Background:
- Colchicine treats gout and familial Mediterranean fever but can cause myopathy and polyneuropathy.
- Risk factors include renal impairment and co-administration with drugs like statins, but patient-specific risks are unclear.
- The ABCB1 gene's role in colchicine metabolism suggests a genetic predisposition to myopathy.
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