Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis

Area of Science:

• Gastroenterology
• Genetics
• Epidemiology

Background:

• Functional dyspepsia (FD) is a prevalent chronic gastrointestinal disorder with unclear etiology.
• Family studies suggest a genetic component in FD pathogenesis.
• Identifying specific gene polymorphisms associated with FD is crucial for understanding its mechanisms.

Purpose of the Study:

• To conduct a systematic review and meta-analysis.
• To evaluate the association between GNB3, SCL6A4, and CCK-1R gene polymorphisms and FD susceptibility.
• To explore potential links to FD subtypes.

Main Methods:

• Systematic literature search of PubMed, EMBASE, Cochrane Library, and HuGE database.
• Meta-analysis using an additive model to assess gene polymorphism associations.
• Subgroup analysis for FD subtypes.

Main Results:

• No significant association was found between GNB3 825C>T, SCL6A4 5HTTLPR, or CCK-1R 779T>C polymorphisms and overall FD susceptibility.
• A subgroup analysis indicated that the minor allele (T) in GNB3 825C>T was associated with increased susceptibility to epigastric pain syndrome (OR = 1.34, P = 0.003).

Conclusions:

• The current meta-analysis suggests that common polymorphisms in GNB3, SCL6A4, and CCK-1R are not generally associated with functional dyspepsia susceptibility.
• The GNB3 825C>T polymorphism may play a role in the epigastric pain syndrome subtype of FD.