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Updated: Jan 23, 2026
The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
The perinatal revolution
Colleen Malloy1, Monique Chireau Wubbenhorst2, Tara Sander Lee3
1Northwestern University Feinberg School of Medicine, Chicago, IL.
Insights
The Perinatal Revolution offers prenatal treatments for fetal diseases, improving lifelong child health. This field advances with new therapies, genetic diagnostics, and innovative technologies.
Area of Science:
- Perinatal Medicine
- Fetal Surgery
- Regenerative Medicine
Background:
- The Perinatal Revolution is a rapidly advancing medical field focused on prenatal disease treatment.
- Current interventions address fetal conditions like myelomeningocele and congenital diaphragmatic hernia.
- Progress in perinatal medicine has improved outcomes for premature neonates.
Purpose of the Study:
- To provide an overview of the perinatal field.
- To emphasize current therapies and interventions for specific fetal problems.
- To discuss novel innovations and future prospects in perinatal medicine.
Main Methods:
- Review of current perinatal therapies and interventions.
- Discussion of advances in screening and genetic diagnosis.
- Exploration of future prospects including cell-based therapies, tissue engineering, gene therapy, and artificial wombs.
Main Results:
- Increased survival rates and improved morbidity/mortality for premature neonates.
- Significant expansion of the field through novel innovations.
- Identification of ethical, regulatory, and policy considerations.
Conclusions:
- The Perinatal Revolution is expanding through research, genetic, medical, and surgical advances.
- Future prospects include significant advancements in cell-based therapies, tissue engineering, gene therapy, and artificial wombs.
- Ethical, regulatory, and policy concerns are integral to clinical practice and public awareness.
Abstract:
The Perinatal Revolution is an exciting and rapidly developing field of medicine that aims to treat and possibly cure disease in the prenatal period, and thereby to improve health across the lifespan of the child. Here we describe an overview of the perinatal field, with specific emphasis on current therapies and interventions for specific fetal problems, such as myelomeningocele and congenital diaphragmatic hernia. Advances in perinatal medicine have resulted in increased survival rates and improvements in morbidity and mortality for premature neonates. Novel innovations in screening and genetic diagnosis, as well as future prospects in cell-based therapies, tissue engineering, gene therapy, and artificial womb are significantly expanding the field and are discussed. Ethical, regulatory and policy concerns closely linked to clinical practice and public awareness are also highlighted as the Perinatal Revolution continues to unfold through research, genetic, medical and surgical advances.
