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Updated: Jan 23, 2026

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
Genomic stratification based on radiosensitivity and PD-L1 for tailoring therapeutic strategies in cervical cancer
Xintong Lyu1, Yuanjun Jiang2, Miao Zhang1
1Department of Radiation Oncology, the First Hospital of China Medical University, Shenyang 110001, Liaoning, PR China.
Abstract:
Aim: We performed an immunogenomic analysis to help identify a model for the cervical cancer therapeutic module. Patients & methods: Patients were divided into groups according to radiosensitivity and PD-L1 expression status. Results: The PD-L1-low-radioresistant (RR) group indicated worse overall survival under radiotherapy. In addition, the PD-L1-low-RR group showed the lowest immunophenoscore and predicted poor response to anti-PD-1 treatment. Differentially expressed genes associated with the PD-L1-low-RR group were found to play a role in the immune response pathways. FGF19 and PLA2G5 were validated to be upregulated in the PD-L1-low-RR group in the Gene Expression Omnibus database, which predicted the overall survival in the The Cancer Genome Atlas. Conclusion: It will be important to test radiosensitivity and PD-L1 stratification to predict the response to strategies in cervical cancer patients.
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