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Related Experiment Video

Updated: Jan 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Adiponectin levels in a large pooled plaque psoriasis study population.

S Gerdes¹, A Pinter², M Biermann³

¹Psoriasis-Center, Department of Dermatology, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany.

The Journal of Dermatological Treatment

|June 11, 2019

Summary

Adiponectin levels in psoriasis patients are primarily determined by metabolic syndrome and body mass index (BMI). Psoriasis severity and treatments like secukinumab/etanercept showed minimal impact on adiponectin.

Keywords:

Adiponectin BMI metabolic syndrome psoriasis

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Area of Science:

Endocrinology
Dermatology
Metabolic Syndrome Research

Background:

Adiponectin, an adipocyte-secreted protein, is implicated in the cardiometabolic comorbidities observed in psoriasis patients.
Understanding adiponectin's role is crucial for managing psoriasis comorbidities.

Purpose of the Study:

To investigate the influence of obesity, metabolic syndrome, psoriasis severity, and treatments (secukinumab/etanercept) on adiponectin levels.
To analyze the relationship between adiponectin and key clinical parameters in psoriasis.

Main Methods:

A post-hoc analysis of three Phase III clinical trials involving patients with moderate to severe plaque psoriasis.
Correlations between Psoriasis Area and Severity Index (PASI), body mass index (BMI), comorbidities, and adiponectin levels were assessed.
The impact of secukinumab, etanercept, and placebo on adiponectin over 52 weeks was evaluated.

Main Results:

Adiponectin levels were inversely correlated with BMI (r = -0.23, p < .0001) and lower in patients without metabolic syndrome.
A weak, clinically irrelevant negative association was found between PASI scores and adiponectin levels (r = -0.065, p = .0004).
Adiponectin levels remained stable during 52 weeks of treatment with secukinumab or etanercept.

Conclusions:

Metabolic syndrome and BMI are significant determinants of adiponectin levels in psoriasis patients.
Psoriasis severity, as measured by PASI, does not have a clinically relevant impact on adiponectin.
Anti-psoriatic treatments with secukinumab or etanercept did not significantly alter adiponectin levels.