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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Novel paradigms in systemic lupus erythematosus
Thomas Dörner1, Richard Furie2
1Department of Medicine and Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany; German Rheumatism Research Center (DRFZ), Berlin, Germany.
Lancet (London, England)
|June 11, 2019
Summary
Systemic lupus erythematosus (SLE) research faces challenges due to disease heterogeneity. Advances in classification criteria and treatment approaches offer hope for better patient outcomes and safer, more effective therapies.
Area of Science:
- Rheumatology and Immunology
- Genetics and Clinical Investigation
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant heterogeneity.
- Despite improved patient outlooks, unmet needs persist, particularly in developing safer and more effective therapies.
Purpose of the Study:
- To review progress in understanding SLE pathogenesis in relation to clinical phenotypes.
- To discuss advancements in clinical research tools and therapeutic strategies for SLE.
- To highlight new developments in classification, remission definitions, and treatment approaches for SLE.
Main Methods:
- Review of recent literature and clinical research findings in SLE.
- Discussion of updated classification criteria from EULAR and ACR.
- Analysis of novel definitions for remission and low disease activity in SLE.
- Examination of new histological classification proposals for lupus nephritis.
Main Results:
- Progress has been made in understanding SLE heterogeneity and its impact on pathogenesis.
- New classification criteria and definitions of remission/low disease activity are being implemented.
- Novel approaches to drug development and treatment recommendations show promise.
Conclusions:
- Addressing SLE heterogeneity is crucial for developing innovative therapies.
- Refined clinical research tools and updated diagnostic/classification criteria are essential.
- Advancements in understanding and treating SLE offer significant promise for improving patient outcomes and reducing disease burden.
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