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Updated: Jan 23, 2026

Fabrication and Application of Rose Bengal-chitosan Films in Laser Tissue Repair
Published on: October 23, 2012
Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review
Noemi Vanerio1,2, Marco Stijnen1, Bas A J M de Mol2
11 LifeTec Group BV, Eindhoven, The Netherlands.
Abstract:
The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. This study is a literature review using the database PubMed. As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.
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