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The relationship between vitamin D level and hepatosteatosis in obese children

Fatma Dursun1, Nelgin Gerenli2, Seyma Meliha Su Dur3

  • 1Department of Pediatric Endocrinology, Umraniye Training and Research Hospital, Istanbul, Turkey.

Northern Clinics of Istanbul
|June 11, 2019
PubMed

Insights

This study found no significant difference in Vitamin D levels between obese children with and without fatty liver disease. Obesity itself appears to be the primary factor associated with nonalcoholic fatty liver disease in this group.

Area of Science:

  • Pediatric Endocrinology
  • Hepatology
  • Nutritional Science

Background:

  • Childhood obesity is rising, increasing risks for nonalcoholic fatty liver disease (NAFLD) and related health issues.
  • Hepatosteatosis, a component of NAFLD, is a growing concern in pediatric populations.
  • Vitamin D deficiency is prevalent and has been explored for its potential role in various chronic conditions.

Purpose of the Study:

  • To investigate the association between 25-hydroxy Vitamin D levels and the presence of hepatosteatosis in obese children.
  • To determine if Vitamin D status is a significant factor in the development of fatty liver in pediatric obesity.

Main Methods:

  • 110 obese children (aged 10-16) were enrolled in a single-season study (September-November).
  • Hepatosteatosis was diagnosed using abdominal ultrasonography.
  • 25-hydroxy Vitamin D levels were compared between children with and without hepatosteatosis.

Main Results:

  • No statistically significant difference in 25-hydroxy Vitamin D levels was found between the hepatosteatosis and non-hepatosteatosis groups.
  • After adjusting for age and sex, Vitamin D levels did not correlate significantly with liver enzymes (AST, ALT) or body mass index.

Conclusions:

  • This study did not find a significant difference in Vitamin D levels between obese children with and without hepatosteatosis.
  • Obesity, independent of Vitamin D status, is strongly associated with nonalcoholic fatty liver disease in children.
  • Larger-scale studies are recommended to further elucidate the role of Vitamin D in pediatric obesity-related hepatosteatosis.
Abstract

Keywords:
HepatosteatosisVitamin Dobese children

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