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Evolution from primordial oligomeric repeats to modern coding sequences.

S Ohno1

  • 1Beckman Research Institute, City of Hope, Duarte, California 91010.

Journal of Molecular Evolution
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

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Early life

Area of Science:

  • Biochemistry
  • Origin of Life
  • Molecular Evolution

Background:

  • Sugar-metabolizing enzymes show remarkable conservation across prokaryotes and eukaryotes.
  • This suggests critical functional elements were established very early in life's history.

Purpose of the Study:

  • To propose a mechanism for the rapid evolution of functional enzymes from simple precursors.
  • To explain the origin of conserved amino acid sequences in sugar-metabolizing enzymes.

Main Methods:

  • Theoretical modeling of prebiotic nucleic acid replication.
  • Analysis of protein structure and sequence conservation.

Main Results:

  • Hypothesizes that early coding sequences were base oligomer repeats, forming periodic polypeptides.

Related Experiment Videos

  • Periodic polypeptides readily form alpha-helical and beta-sheet structures, common in enzymes.
  • Prebiotic replication favored internal double nucleotide oligomers, enabling template elongation.

    • Conclusions:

    • Initial biological innovation stemmed from repetitive genetic sequences.
    • This process allowed for the rapid emergence of complex, functional proteins like sugar-metabolizing enzymes.