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Repetitive transcranial magnetic stimulation for functional tremor: A randomized, double-blind, controlled study
Simon Taib1,2, Fabienne Ory-Magne2,3, Christine Brefel-Courbon2,3
1Psychiatry and Medical Psychology Department, Toulouse University Hospital, Toulouse, France.
Summary
Active repetitive transcranial magnetic stimulation (rTMS) significantly improved functional tremor symptoms for up to 12 months. Sham rTMS offered no lasting benefit, suggesting rTMS is a valuable treatment for functional tremor.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Functional tremor is a disabling neurological condition lacking effective long-term treatments.
- Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique with potential therapeutic applications.
Purpose of the Study:
- To compare the efficacy of active versus sham rTMS in treating functional tremor.
- To investigate if hypnosis enhances or prolongs the therapeutic effects of rTMS.
Main Methods:
- A randomized, double-blind, parallel-controlled study involving 18 outpatients with functional tremor.
- Patients received 5 daily sessions of active or sham rTMS, followed by an open-label phase combining hypnosis with real rTMS.
- Outcomes were assessed using the Psychogenic Movement Disorder Rating Scale and other clinical scales at multiple time points up to 12 months.
Main Results:
- Active rTMS led to significant reductions in functional tremor severity at 1 and 2 months, which were maintained at 6 and 12 months.
- The sham rTMS group showed only transient improvements, with scores returning to baseline by 2 months.
- No significant long-term benefits were observed with sham rTMS.
Conclusions:
- Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic option for managing functional tremor.
- The study highlights the sustained efficacy of active rTMS in improving tremor symptoms.
- Further research into adjunctive therapies like hypnosis may be warranted.
Keywords:
cortical neuromodulationfunctional tremorhypnosisrepetitive transcranial magnetic stimulationMore Related Videos
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