Related Experiment Video

Updated: Jan 23, 2026

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
05:51

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

2.3K

Development of Theragnostic Tool Using NIR Fluorescence Probe Targeting Mitochondria in Glioma Cells

Yeonjeong Chu1,2, Min Chul Shin1, June Sung1

  • 1Department of Molecular Science and Technology , Ajou University , Suwon 16499 , Republic of Korea.

Bioconjugate Chemistry
|June 11, 2019
PubMed

Insights

A novel near-infrared fluorescent probe, SiR-Mito11, selectively targets brain tumor cells, disrupting mitochondria and inducing cancer cell death while sparing normal neurons.

Area of Science:

  • Mitochondrial biology
  • Cancer therapy
  • Biomedical imaging

Background:

  • Mitochondria are crucial for cellular energy and apoptosis.
  • Mitochondrial dysfunction is a target for anticancer strategies.
  • Targeting brain tumors requires agents with high specificity.

Purpose of the Study:

  • To develop a theragnostic agent for brain tumors.
  • To investigate a new near-infrared fluorescent probe, SiR-Mito11.
  • To evaluate the selective anticancer activity of SiR-Mito11.

Main Methods:

  • Synthesis and characterization of SiR-Mito11.
  • In vitro evaluation of SiR-Mito11 on glioma and normal neuronal cells.
  • Assessment of mitochondrial membrane potential disruption and apoptosis induction.

Main Results:

  • SiR-Mito11 demonstrated selective accumulation in glioma cells.
  • The probe exhibited anticancer activity against glioma cells.
  • Normal neuronal cells showed tolerance to SiR-Mito11.
  • SiR-Mito11 disrupted mitochondrial membrane potential, leading to apoptosis.

Conclusions:

  • SiR-Mito11 is a promising theragnostic agent for brain tumors.
  • Selective mitochondrial targeting offers a potential therapeutic strategy.
  • SiR-Mito11 warrants further investigation for clinical application.

More Related Videos

Isolation of Conditionally Immortalized Mouse Glomerular Endothelial Cells with Fluorescent Mitochondria11:49

Isolation of Conditionally Immortalized Mouse Glomerular Endothelial Cells with Fluorescent Mitochondria

Published on: September 13, 2022

2.6K
Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

16.4K

Related Concept Videos

Peroxisomes and Mitochondria01:30

Peroxisomes and Mitochondria

Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
94.6K
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.8K
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
12.4K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
5.3K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
6.6K
Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
9.3K