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Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized
Yingna Liu1,2, Firas Jassim1,3, Boy Braaf1,4
1Harvard Medical School.
Journal of Glaucoma
|June 11, 2019
Summary
Peripapillary retinal volume (RV) offers similar diagnostic capability for glaucoma as retinal nerve fiber layer (RNFL) thickness. RV measurements result in significantly fewer artifacts, improving diagnostic reliability.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Diagnostics
Background:
- Glaucoma diagnosis relies on detecting structural changes in the optic nerve head.
- Peripapillary retinal nerve fiber layer (RNFL) thickness is a standard biomarker.
- Artifacts in RNFL measurements can hinder accurate glaucoma assessment.
Purpose of the Study:
- To compare the diagnostic performance of 3D peripapillary retinal volume (RV) against 2D peripapillary RNFL thickness.
- To evaluate diagnostic accuracy for open-angle glaucoma detection.
Main Methods:
- Retrospective analysis of 180 participants (113 glaucoma, 67 controls).
- Spectral domain optical coherence tomography (SD-OCT) volume scans and RNFL thickness data were used.
- Peripapillary RV calculated using custom software across four circumpapillary annuli (CA1-CA4).
- Area under the receiver operating characteristic curves (AUC) determined for diagnostic capability.
Main Results:
- Peripapillary RV demonstrated diagnostic capability comparable to RNFL thickness (P>0.05).
- The inferior RV quadrant showed the highest performance across all annuli.
- RV exhibited a significantly lower artifact rate (6.0%) compared to RNFL thickness (32.2%, P<0.0001).
Conclusions:
- Peripapillary RV is a viable alternative to RNFL thickness for diagnosing glaucoma.
- RV offers improved diagnostic reliability due to a substantially lower incidence of artifacts.
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