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T cell-derived blast crisis in chronic myelocytic leukemia
J P Fermand1, F Sigaux, A Tsapis
1Laboratoire d'Immunochimie et d'Immunopathologie (INSERM U108), Hôpital Saint-Louis, Paris, France.
Leukemia
|March 1, 1987
Abstract:
We describe herein the occurrence of a T cell-derived blast crisis of chronic myelocytic leukemia which presented as a typical T cell leukemia on clinical (thymic mass and high white blood cells) and immunological grounds (T6+ T4+ T8+), with rearranged T cell receptor genes and germ line immunoglobulin genes. A Philadelphia chromosome was detected in all blast cell mitoses. The significance of T cell involvement during the chronic and acute phases of chronic myelocytic leukemia is discussed.