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The effect of cerebral palsy on neonatal line thickness and enamel components

Fanny Hershkovitz1, Leibovitz Shirley1, Ornit Cohen1

  • 1Pediatric Dental Clinic, Barzilai Medical University Center, Ashkelon, Israel.

Archives of Oral Biology
|June 11, 2019
PubMed

Insights

Children with cerebral palsy (CP) have narrower neonatal lines in their deciduous teeth. Their pre-natal enamel also shows higher concentrations of magnesium and sodium compared to healthy children.

Area of Science:

  • Pediatric Dentistry
  • Developmental Biology
  • Biomineralization

Background:

  • Cerebral palsy (CP) affects motor development and can impact systemic health.
  • Enamel formation, particularly the neonatal line, reflects early developmental conditions.
  • Deciduous teeth provide a record of pre-natal and early post-natal development.

Purpose of the Study:

  • To compare neonatal line width in deciduous teeth of children with CP versus healthy controls.
  • To analyze the elemental composition of pre-natal and post-natal enamel in these groups.
  • To investigate potential correlations between CP and enamel development.

Main Methods:

  • Analysis of 58 deciduous teeth (29 from children with CP, 29 from controls).
  • Microscopic examination (light and scanning electron microscopy) of tooth sections.
  • Measurement of neonatal line width and elemental composition (Ca, P, Si, Mg, Na, O, C) using ESD.

Main Results:

  • Neonatal lines were significantly narrower in children with CP.
  • Pre-natal enamel showed higher magnesium and sodium concentrations in both groups compared to post-natal enamel.
  • Children with CP exhibited significantly higher pre-natal enamel magnesium and sodium levels than controls.

Conclusions:

  • Narrower neonatal lines in deciduous teeth may be indicative of CP.
  • Elevated pre-natal magnesium and sodium concentrations in enamel are associated with CP.
  • These findings suggest altered mineral metabolism during early development in children with CP.
Abstract

Keywords:
Cerebral palsyEnamelIon contentsMagnesiumNeo-natal line

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