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ZBTB46, SPDEF, and ETV6: Novel Potential Biomarkers and Therapeutic Targets in Castration-Resistant Prostate Cancer

AbdulFattah Salah Fararjeh1, Yen-Nien Liu2,3,4

  • 1PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. d621104004@tmu.edu.tw.

International Journal of Molecular Sciences
|June 12, 2019
PubMed

Insights

Prostate cancer (PCa) progression to castration-resistant PCa (CRPC) involves unclear mechanisms. This review highlights three biomarkers (ZBTB46, SPDEF, ETV6) crucial for understanding CRPC development and resistance to therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer (PCa) is a leading cause of cancer death in men.
  • Androgen deprivation therapy (ADT) is standard for metastatic PCa but often leads to castration-resistant PCa (CRPC).
  • The precise mechanisms driving CRPC development remain incompletely understood, though AR signaling persistence is implicated.

Purpose of the Study:

  • To review novel biomarkers involved in CRPC progression.
  • To explore the roles of ZBTB46, SPDEF, and ETV6 in CRPC.
  • To discuss the clinical utility of these biomarkers for diagnosis and therapy.

Main Methods:

  • Literature review focusing on recent studies of CRPC mechanisms.
  • Analysis of the roles of ZBTB46, SPDEF, and ETV6 in AR signaling and treatment resistance.
  • Synthesis of information on biomarker potential in clinical settings.

Main Results:

  • ZBTB46, SPDEF, and ETV6 are identified as key players in CRPC.
  • These biomarkers are linked to resistance against androgen deprivation therapy (ADT) and EGFR TKI.
  • They also play a role in epithelial-to-mesenchymal transition (EMT) during CRPC progression.

Conclusions:

  • Understanding AR signaling in CRPC is vital for new therapeutic strategies.
  • ZBTB46, SPDEF, and ETV6 show promise as diagnostic and therapeutic targets for PCa and CRPC.
  • Further research into these biomarkers could improve patient outcomes.
Keywords:
ETS variant gene 6 (ETV6)SAM pointed domain containing ETS transcriptional factor (SPDEF)androgen receptor (AR)castration-resistant prostate cancer (CRPC)zinc finger and BTB domain-containing protein 46 (ZBTB46)

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