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RADIATE - Radial Dysplasia Assessment, Treatment and Aetiology: protocol for the development of a core outcome set

George R F Murphy1,2, Malcolm Logan3, Gill Smith4

  • 1Department of Plastic Surgery, Great Ormond Street Hospital for Children, London, WC1N 3JH, UK. george.murphy@gosh.nhs.uk.

Trials
|June 12, 2019
PubMed

Insights

This study establishes a core outcome set for radial dysplasia (RD), a congenital upper limb anomaly. This will standardize outcome measurement for improved treatment of children with RD.

Area of Science:

  • Orthopedics
  • Congenital Anomalies
  • Outcomes Research

Background:

  • Radial dysplasia (RD) is a congenital upper limb anomaly with varied surgical treatments and no established core outcome set.
  • Current literature on RD is characterized by retrospective studies with heterogeneous outcome measurement.
  • A systematic review highlighted significant variability in outcome assessment for RD.

Purpose of the Study:

  • To establish a core outcome set for radial dysplasia (RD).
  • To address uncertainty in the optimal treatment of forearm and hand anomalies in children with RD.
  • To standardize outcome measurement in RD research and clinical practice.

Main Methods:

  • A three-round online Delphi process involving patients, parents, hand surgeons, and therapists.
  • Outcomes list derived from a systematic review and stakeholder input.
  • Consensus on outcome definitions will be ratified at a final meeting, followed by instrument selection using COSMIN guidelines.

Main Results:

  • (Study ongoing, results to be determined)

Conclusions:

  • The RADIATE study aims to provide a standardized approach to outcome measurement in radial dysplasia.
  • Establishing a core outcome set will facilitate evidence-based treatment decisions for RD.
Abstract

Keywords:
Radial dysplasia, Congenital upper limb anomalies, core outcome set, Congenital hand surgery

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