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Elevated serum preptin concentrations in patients with diabetic nephropathy
Rui Wang1, Aili Xue2, Wenjian Zheng3
1Department of Blood Transfusion, Qilu Hospital of Shandong University (Qingdao), Qingdao, China.
Serum preptin levels are elevated in patients with type 2 diabetes mellitus and diabetic nephropathy. Higher preptin concentrations correlate with increased risk and severity of diabetic nephropathy, indicating its potential as a biomarker.
Area of Science:
- Endocrinology
- Nephrology
- Metabolic Diseases
Background:
- Preptin is a peptide co-secreted with insulin by pancreatic beta cells.
- Diabetic nephropathy (DN) is a major complication of type 2 diabetes mellitus (T2DM).
Purpose of the Study:
- To investigate the association between serum preptin concentrations and diabetic nephropathy in T2DM patients.
Main Methods:
- Cross-sectional study involving 234 T2DM patients and 78 healthy controls.
- T2DM patients classified into normoalbuminuria (DN0), microalbuminuria (DN1), and macroalbuminuria (DN2) groups based on urine albumin to creatinine ratio (ACR).
- Serum preptin levels analyzed using logistic and linear regression to assess correlations with DN and clinical parameters.
Main Results:
- Serum preptin concentrations were significantly higher in all T2DM subgroups compared to controls.
- A graded increase in serum preptin was observed from DN0 to DN2 groups.
- Serum preptin positively correlated with gender, BMI, blood urea nitrogen, creatinine, and ACR, and negatively with estimated glomerular filtration rate and certain diabetes medications.
Conclusions:
- Serum preptin levels are associated with the presence and severity of diabetic nephropathy in T2DM.
- Preptin may serve as a potential biomarker for assessing renal function and DN risk in diabetic patients.
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