Metformin prevents murine ovarian aging

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Xian Qin1,2, Dingfu Du1, Qian Chen1

  • 1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Aging
|June 12, 2019
PubMed

Insights

Metformin treatment improved female reproductive lifespan in mice by enhancing ovarian function and delaying aging. This study shows metformin delays ovarian aging, likely by increasing SIRT1 expression and reducing oxidative damage.

Area of Science:

  • Reproductive biology
  • Gerontology
  • Pharmacology

Background:

  • Metformin is known to delay aging and extend lifespan in animals.
  • Its specific effects on female reproductive lifespan, particularly ovarian aging, remain unclear.

Purpose of the Study:

  • To investigate the anti-aging effects of metformin on the ovary.
  • To elucidate the underlying mechanisms of metformin's action on ovarian aging.

Main Methods:

  • Female C57BL/6 mice were divided into control and metformin-treated groups for six months.
  • Ovarian reserve, estrous cycle, hormone levels, and expression of aging markers (P16, SIRT1, oxidative metabolites) were assessed.

Main Results:

  • Metformin-treated mice showed improved estrous cycle regularity and increased serum E2 hormone levels.
  • Significant increases in primordial/primary follicles and SIRT1 expression were observed.
  • Decreased levels of aging markers (P16) and oxidative damage indicators (8-OHdG, 4-HNE) were noted.

Conclusions:

  • Metformin effectively delays ovarian aging in mice.
  • The mechanism likely involves upregulation of SIRT1 and reduction of oxidative stress.
Keywords:
SIRT1metforminovarian agingoxidative stress

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