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Histamine modulates hippocampal inflammation and neurogenesis in adult mice

Cláudia Saraiva1, Sandra Barata-Antunes1, Tiago Santos1

  • 1CICS-UBI - Health Sciences Research Centre, University of Beira Interior, 6201-001, Covilhã, Portugal.

Scientific Reports
|June 12, 2019
PubMed

Insights

Histamine exhibits a dual role in neuroinflammation and neurogenesis. In inflammatory conditions, histamine counteracts lipopolysaccharide (LPS)-induced neuroinflammation and neurogenesis impairment, suggesting therapeutic potential.

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Histamine plays a complex role in microglia-mediated neuroinflammation.
  • Histamine is implicated in modulating adult neurogenesis.
  • Neuroinflammation and impaired neurogenesis are hallmarks of neurodegenerative diseases.

Purpose of the Study:

  • To investigate the effects of histamine on hippocampal neuroinflammation and neurogenesis.
  • To determine histamine's role in both physiological and inflammatory states.
  • To assess histamine's therapeutic potential in neurological disorders.

Main Methods:

  • Mice were challenged with lipopolysaccharide (LPS) to induce inflammation.
  • Histamine was administered intrahippocampally.
  • Neuroinflammation, glial reactivity, and neurogenesis markers were analyzed.

Main Results:

  • Histamine alone induced glial reactivity and mild neurogenesis deficits.
  • In LPS-challenged mice, histamine mitigated glial activation and pro-inflammatory cytokine release.
  • Histamine protected against LPS-induced neurogenesis impairment and loss of neuronal proteins (CREB, PSD-95).

Conclusions:

  • Histamine demonstrates a dual role, exacerbating neuroinflammation at baseline but offering protection under inflammatory conditions.
  • Histamine may serve as a therapeutic agent for neurological conditions characterized by hippocampal neuroinflammation and neurodegeneration.

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