Related Experiment Video

Updated: Jan 23, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Published on: February 16, 2018

Synthesis of a one-handed helical polythiophene: a new approach using an axially chiral bithiophene with a fixed

Tomoyuki Ikai¹, Kokoro Takayama¹, Yuya Wada¹

¹Graduate School of Natural Science and Technology , Kanazawa University , Kakuma-machi , Kanazawa 920-1192 , Japan .

Chemical Science

|June 12, 2019

Abstract:

We report an optically active polythiophene capable of forming a one-handed helically folded conformation without needing aggregate formation, poor solvent conditions, hydrogen-bonded ion-pair formation or guest addition. The target polythiophene (poly-T_R) with a static axial chirality in the main chain was synthesized via Stille coupling copolymerization of a glucose-linked chiral 5,5'-dibromobithiophene with 2,5-bis(stannyl)thiophene. Poly-T_R showed a characteristic circular dichroism and circularly polarized luminescence, which were completely different to those observed for an analogous polymer (poly-Ph_R) and the corresponding unimer/dimer model compounds. This chiroptical study, combined with the results of all-atom molecular dynamics simulations, revealed that poly-T_R can fold into a left-handed helical conformation under good solvent conditions. Partial conformational regulation derived from the fixed syn-conformation of the chiral bithiophene unit was considered a key factor in producing the one-handed helical polythiophene.

More Related Videos

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals

Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals

Published on: May 25, 2016

Related Concept Videos

Conformity

Conformity

Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.

Chirality

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

Chirality in Nature

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.

Axial and Appendicular Muscles

Axial and Appendicular Muscles

Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...

General Case of Eccentric Axial Loading

General Case of Eccentric Axial Loading

Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...

Overview of the Axial Skeleton

Overview of the Axial Skeleton

The skeleton is subdivided into two major divisions—the axial skeleton and the appendicular skeleton. The axial skeleton forms the vertical, central axis of the body. It includes all of the bones of the head, neck, chest, and back. It protects the brain, spinal cord, heart, and lungs. It also serves as the attachment site for muscles that move the head, neck, and back and for muscles that act across the shoulder and hip joints to move their corresponding limbs.
The axial skeleton of the...

Articles linked to this work by shared authors, journal, and citation graph.

"Learning bystander activation": resident-led diagnostic error case conferences and sustained reflective engagement among junior residents.

Diagnosis (Berlin, Germany)·2026

Dynamic helical poly[4]helicene nanoribbon.

Nature communications·2026

Skeletal transformation to chiral nanocarbon molecules.

Nature communications·2026

Inner-Bond Cleavage of Sterically Congested Dibenzo[g,p]chrysene to a Rigid Figure-Eight Macrocycle.

Organic letters·2026

Ladderization: A Powerful Strategy for Controlling Supramolecular Helical Ordering, Amplifying Asymmetry, and Emerging and Enhancing Circularly Polarized Luminescence.

Small (Weinheim an der Bergstrasse, Germany)·2026

Examining atypical presentations associated with a higher risk of diagnostic errors using a new classification model.

Diagnosis (Berlin, Germany)·2026

See all related articles