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Related Experiment Video

Updated: Jan 23, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Can Platelet Indices Reduce Negative Appendectomy Rates?

Yavuz Yigit1, Serkan Yilmaz2, Asim E Ozbek1

  • 1Emergency Medicine, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Kocaeli, TUR.

Cureus
|June 12, 2019
PubMed
Summary
This summary is machine-generated.

This study found that mean platelet volume (MPV) and platelet distribution width (PDW) are not useful for diagnosing acute appendicitis. These platelet indices showed no significant differences across patient groups, suggesting they are unreliable markers for this condition.

Keywords:
appendicitisblood cell countmean platelet volume

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Area of Science:

  • Medical diagnostics
  • Hematology
  • Surgical pathology

Background:

  • Whole blood count parameters are frequently studied for inflammatory diseases.
  • Platelet parameters like MPV and PDW have shown contradictory results in appendicitis diagnosis.
  • Acute appendicitis diagnosis often relies on inflammatory markers, but novel indicators are sought.

Purpose of the Study:

  • To evaluate the diagnostic utility of mean platelet volume (MPV) and platelet distribution width (PDW) in acute appendicitis.
  • To compare MPV and PDW values between patients with non-appendicitis, uncomplicated appendicitis, and complicated appendicitis.
  • To assess the role of platelet indices alongside traditional markers like WBC and CRP.

Main Methods:

  • Retrospective screening of medical records for patients over 15 who underwent appendectomy.
  • Categorization of patients into non-appendicitis, uncomplicated appendicitis, and complicated appendicitis groups.
  • Calculation of sensitivity, specificity, predictive values, and likelihood ratios for WBC, neutrophil count, CRP, MPV, and PDW.

Main Results:

  • No significant differences were observed in MPV values across the three patient groups (p = 0.141).
  • No significant differences were found in PDW values among the groups (p = 0.228).
  • Only a small fraction of appendicitis patients had normal CRP and WBC values, indicating the complexity of diagnosis.

Conclusions:

  • Platelet indices, specifically MPV and PDW, are not effective diagnostic markers for acute appendicitis.
  • Various factors influence MPV and PDW, limiting their reliability in this clinical context.
  • Further research may be needed to identify reliable platelet-based biomarkers for appendicitis.