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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Nursing Clinical Information System (NCIS)
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Clinical Trials01:16

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Jan 23, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Tumor-Activatable Clinical Nanoprobe for Cancer Imaging.

Derek Reichel1, Manisha Tripathi1,2, Pramod Butte1

  • 1Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048.

Nanotheranostics
|June 12, 2019
PubMed
Summary
This summary is machine-generated.

A novel fluorescent nanoprobe, FH(ICG), enhances tumor visualization during cancer surgery. This probe offers improved signal-to-noise ratio and long-term fluorescence for accurate tumor detection and guided therapy.

Keywords:
FerahemeIndocyanine greenfluorescence imagingimage-guided surgeryprostate cancer

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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Surgical Oncology

Background:

  • Accurate tumor boundary identification is crucial for successful cancer surgery.
  • Intra-operative tumor visualization remains a significant challenge in surgical oncology.
  • Current fluorescent probes lack stability, clinical translatability, and optimal signal-to-noise ratios for effective tumor delineation.

Purpose of the Study:

  • To develop and evaluate a novel fluorescent nanoprobe for enhanced intra-operative tumor visualization.
  • To overcome the limitations of existing fluorescent agents in cancer surgery.
  • To create a clinically translatable imaging agent with high signal-to-noise ratio and low background fluorescence.

Main Methods:

  • Screened optical properties of fluorescent dyes pre- and post-nanoprobe encapsulation.
  • Investigated in vitro physical and biological properties of nanoprobes for fluorescence activation.
  • Compared in vivo cancer imaging properties of free dyes versus nanoprobe-encapsulated dyes in a prostate cancer mouse model.

Main Results:

  • Developed a novel FH(ICG) nanoprobe combining FDA-approved Feraheme and indocyanine green.
  • FH(ICG) nanoprobes exhibited quenched fluorescence, re-activated in acidic tumor microenvironments and upon cancer cell uptake.
  • In vivo studies showed enhanced, long-term tumor fluorescence with FH(ICG) compared to ICG, enabling fluorescence-guided identification.

Conclusions:

  • FH(ICG) nanoprobes demonstrate superior fluorescence activation properties compared to other FH-entrapped dyes.
  • The activatable nature of FH(ICG) provides low background and high signal-to-noise ratios for effective tumor visualization.
  • This nanoprobe represents a promising, clinically translatable tool for image-guided cancer therapy.