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Updated: Jan 23, 2026

Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells
Published on: January 12, 2024
Mesenchymal Stem Cells from Mouse Adipose Tissue Stimulate Tumor Growth
E Yu Moskaleva1, Yu P Semochkina2, V G Shuvatova2
1Laboratory of Cell Biology and Molecular Medicine, National Research Center Kurchatov Institute, Moscow, Russia. moskalevaey@mail.ru.
Abstract:
We studied the effect of mesenchymal stem cells from the bone marrow and adipose tissue on the growth rate of melanoma B16 and mammary adenocarcinoma Ca755 tumors after their co-administration with tumor cells to syngeneic mice. Stimulation of tumor growth and formation of melanoma metastases in the lungs was found under the influence of adipose tissue-derived, but not bone marrow-derived stem cells. At delayed terms after irradiation in sublethal doses, the adipose tissue-derived mesenchymal stem cells also stimulated the tumor growth. Stimulation of the tumor growth by adipose tissue-derived mesenchymal stem cells was caused by factors secreted by these cells. Transplantation of mesenchymal stem cells to humans is possible only after accurate exclusion of malignant tumors.
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