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Spontaneous Activity and the Urinary Bladder.

Christopher H Fry1, Karen D McCloskey2

  • 1School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK. chris.fry@bristol.ac.uk.

Advances in Experimental Medicine and Biology
|June 12, 2019
PubMed
Summary
This summary is machine-generated.

Spontaneous bladder contractions, both normal and overactive, arise from complex bladder wall structures. Understanding these contractions is key to bladder function and treating overactive bladder conditions.

Keywords:
Detrusor smooth muscleMucosaOveractive bladderSpontaneous contractionsTrigoneUrinary bladder

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Area of Science:

  • Urology
  • Physiology
  • Cell Biology

Background:

  • The urinary bladder stores urine when relaxed and voids when intravesical pressure increases.
  • Spontaneous contractions occur in normal bladders and pathological detrusor overactivity, impacting bladder compliance and function.
  • The bladder wall's complex structure, including mucosa and lamina propria with sensory nerves, influences these contractions.

Purpose of the Study:

  • To characterize spontaneous contractions in the urinary bladder.
  • To understand the mechanisms maintaining normal bladder compliance during filling.
  • To elucidate the pathophysiology of detrusor overactivity and its causes.

Main Methods:

  • Review of existing theories on spontaneous bladder contraction origins.
  • Consideration of evidence for each theory in normal and overactive bladders.
  • Analysis of how aging and development affect these mechanisms.

Main Results:

  • Multiple theories exist for spontaneous contractions: detrusor muscle rhythmicity, non-muscular pacemaking cells, autonomic nerve input, mucosal regulation, and lamina propria activity.
  • The structural complexity of the bladder wall is crucial for understanding contraction origins.
  • Mechanisms may vary with age and development.

Conclusions:

  • Understanding spontaneous contractions is vital for normal bladder function and treating detrusor overactivity.
  • Further research into these mechanisms could reveal novel therapeutic targets for bladder dysfunction.
  • The interplay between detrusor muscle, mucosa, and associated structures drives bladder activity.