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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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Development of the Lymphatic System01:15

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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ATP Driven Pumps III: V-type Pumps01:30

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V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
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ATP Driven Pumps II: P-type Pumps01:34

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The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
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Introduction to Lymphatic and Immune System01:22

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
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Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
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Related Experiment Video

Updated: Jan 23, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
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Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

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Lymphatic Vessel Pumping.

Pierre-Yves von der Weid1

  • 1Department of Physiology and Pharmacology, Inflammation Research Network and Smooth Muscle Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. vonderwe@ucalgary.ca.

Advances in Experimental Medicine and Biology
|June 12, 2019
PubMed
Summary
This summary is machine-generated.

The lymphatic system

Keywords:
Ca2+-activated Cl− channelIntracellular Ca2+ storeLymphatic muscle cellLymphatic pacemakerLymphatic pumpingLymphatic systemLymphatic vesselSpontaneous transient depolarization

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Related Experiment Videos

Last Updated: Jan 23, 2026

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Area of Science:

  • Physiology
  • Lymphatic System
  • Vascular Biology

Background:

  • The lymphatic system collects excess interstitial fluid, transporting proteins, immune cells, and fats.
  • This system is crucial for maintaining tissue fluid balance, fat metabolism, and immune responses.
  • Lymphatic vessels propel lymph via rhythmic contractions, a process vital for fluid homeostasis.

Purpose of the Study:

  • To elucidate the mechanisms driving spontaneous lymphatic pumping.
  • To explore the physiological initiation of lymphatic vessel contractions.
  • To review recent advancements in understanding lymphatic contractile function.

Main Methods:

  • Analysis of spontaneous contractions in isolated lymphatic vessels.
  • Investigation of regulatory factors including transmural pressure, flow rate, and molecular signaling.
  • Review of current research on lymphatic pumping mechanisms.

Main Results:

  • Lymphatic pumping relies on voltage-gated Ca2+ channel-induced action potentials in smooth muscle cells.
  • Spontaneous contractions are initiated by intrinsic pacemaker mechanisms.
  • Lymphatic pumping is modulated by physical stimuli and paracrine factors.

Conclusions:

  • Understanding lymphatic pumping is key to comprehending fluid balance and immune function.
  • The study highlights the complex interplay of intrinsic and extrinsic factors regulating lymphatic transport.
  • Further research into lymphatic pumping mechanisms holds therapeutic potential.