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Chronobiology of lithium--studies on healthy, middle-aged women
1Central Psychiatric Department, Johann Wolfgang Goethe University Frankfurt/Main, FRG.
3 women aged 37, 44 and 53 years were examined in a long term study (4-5 months) with and without lithium carbonate medication. The subjective condition and complaints of the subjects were recorded. The body temperature was measured each night with a rectal probe and the data analysed using TIMESDIA-program. During the lithium medication, deterioration in the subjects well-being, and somatic disturbances can occur. At the same time variations in the circadian course of the body temperature were demonstrated. In addition to the 24-hour period, longer and shorter periods appear. Based on a chronobiological model a possible dissociation of the oscillator controlling body temperature is suggested.
3 women aged 37, 44 and 53 years were examined in a long term study (4-5 months) with and without lithium carbonate medication. The subjective condition and complaints of the subjects were recorded. The body temperature was measured each night with a rectal probe and the data analysed using TIMESDIA-program. During the lithium medication, deterioration in the subjects well-being, and somatic disturbances can occur. At the same time variations in the circadian course of the body temperature were demonstrated. In addition to the 24-hour period, longer and shorter periods appear. Based on a chronobiological model a possible dissociation of the oscillator controlling body temperature is suggested.