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Updated: Jan 23, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Asymmetric Synthesis and Chiroptical Properties of Enantiopure Helical Ferrocenes
Antonio Urbano1,2, Ana M Del Hoyo1, Alicia Martínez-Carrión1
1Departamento de Química Orgánica , Universidad Autónoma de Madrid (UAM) , Cantoblanco , 28049 Madrid , Spain.
Abstract:
An enantiopure helical ferrocene ( Rp)-5 with five ortho-condensed aromatic rings was synthesized using a PtCl2-catalyzed cycloisomerization of planar-chiral 2-ethynyl-1-(4-phenanthrenyl)ferrocene ( Rp)-6f, prepared in 3 steps from known enantiopure sulfinyl ferrocenyl boronic acid ( SS, Sp)-7, as the source of planar chirality. This pentacyclic helical ferrocene showed a very high optical rotation value and strong circular dichroism (CD) signals.
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