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Evaluation of cerebrovascular reactivity in chronic hepatitis C patients using transcranial color Doppler

Mirela Pavicic Ivelja1, Ivo Ivic1, Kresimir Dolic2

  • 1Department of Infectious Diseases, University Hospital Split, Split, Croatia.

Plos One
|June 12, 2019
PubMed

Insights

Chronic Hepatitis C infection is linked to reduced cerebrovascular reactivity. This finding suggests a potential increased risk of cerebrovascular diseases in patients with Hepatitis C viral infection.

Area of Science:

  • Neurology
  • Hepatology
  • Vascular Medicine

Background:

  • Hepatitis C viral (HCV) infection is associated with systemic inflammation and metabolic complications.
  • These complications may increase the risk of atherosclerosis, including cerebrovascular atherosclerosis.

Purpose of the Study:

  • To assess cerebrovascular reactivity in patients with chronic Hepatitis C infection.
  • To investigate the potential link between HCV and cerebrovascular health.

Main Methods:

  • A cohort of 17 patients with chronic Hepatitis C infection and 11 healthy controls were studied.
  • Cerebrovascular reactivity was assessed using the breath-holding test with transcranial color Doppler to measure blood flow velocity.

Main Results:

  • Patients with chronic HCV exhibited significantly lower average peak systolic, end-diastolic, and mean velocities at the start of breath-holding.
  • Lower mean peak systolic velocity at the end of breath-holding and reduced vascular reactivity (breath-holding index) were observed in the HCV group.
  • Statistical significance was noted for all key findings (P < 0.05).

Conclusions:

  • The study suggests an association between chronic HCV infection and altered cerebrovascular reactivity.
  • This alteration may negatively impact cerebrovascular hemodynamics.
  • An increased risk of cerebrovascular diseases is a potential consequence in patients with chronic HCV infection.

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