Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

38.3K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.3K
The Extracellular Matrix01:42

The Extracellular Matrix

88.3K
Overview
88.3K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

22.1K
Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.1K
Transcription Factors02:16

Transcription Factors

82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K
Fast Fourier Transform01:10

Fast Fourier Transform

927
The Fast Fourier Transform (FFT) is a computational algorithm designed to compute the Discrete Fourier Transform (DFT) efficiently. By breaking down the calculations into smaller, manageable sections, the FFT significantly reduces the computational complexity involved. Direct computation of an N-point DFT requires N2 complex multiplications, whereas the FFT algorithm needs only (N/2)log⁡2N multiplications, offering a much faster performance.
The computational efficiency of the FFT becomes...
927
Optimal Foraging00:48

Optimal Foraging

13.7K
How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
13.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantum-machine-assisted drug discovery.

npj drug discovery·2026
Same author

Embeddings of clinical codes enable knowledge-grounded AI in medicine.

NPJ digital medicine·2026
Same author

From text to translation: using language models to prioritize variants for clinical review.

Genome medicine·2026
Same author

Phenotypic prediction of missense variants via deep contrastive learning.

Nature biomedical engineering·2026
Same author

Toward AI-Powered Cancer Etiology Research.

Cancer discovery·2026
Same author

Geranium: Multimodal Retrieval of Genomics Data Visualizations.

IEEE transactions on visualization and computer graphics·2026
Same journal

Thymidylate synthase inhibitory drugs induce p53-dependent pathways differently.

PloS one·2026
Same journal

Top-down and bottom-up attention for joint pattern classification and reconstruction.

PloS one·2026
Same journal

Short- and long-term scaling behavior of blood pressure and pulse arrival time during sleep in healthy controls and patients with obstructive sleep apnea.

PloS one·2026
Same journal

Double DQN-based secrecy energy efficiency and fairness performance in IRS-assisted NOMA systems with friendly jamming.

PloS one·2026
Same journal

10 recommendations for strengthening citizen science for improved societal and ecological outcomes: A co-produced analysis of challenges and opportunities in the 21st century.

PloS one·2026
Same journal

Paying in public: Peer effects, impression management, and willingness to pay on digital payment platforms.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Jan 23, 2026

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix
08:46

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

13.9K

Fast optimization of non-negative matrix tri-factorization.

Andrej Čopar1, Blaž Zupan1,2, Marinka Zitnik1,3

  • 1Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia.

Plos One
|June 12, 2019
PubMed
Summary
This summary is machine-generated.

New optimization methods for Non-negative matrix tri-factorization (NMTF) significantly outperform traditional multiplicative updates. Projected gradients and coordinate descent offer substantial speed improvements for learning low-dimensional representations.

More Related Videos

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

10.1K
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

14.2K

Related Experiment Videos

Last Updated: Jan 23, 2026

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix
08:46

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

13.9K
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

10.1K
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

14.2K

Area of Science:

  • Machine Learning
  • Data Mining
  • Numerical Analysis

Background:

  • Non-negative matrix tri-factorization (NMTF) is key for low-dimensional feature learning in relational data.
  • Current NMTF optimization using multiplicative updates has limitations and poorly understood failure modes.

Purpose of the Study:

  • To empirically compare NMTF optimization methods on large datasets.
  • To identify faster and more robust optimization techniques for NMTF.

Main Methods:

  • Empirical study on six large datasets.
  • Comparison of multiplicative update rules against alternating least squares, projected gradients, and coordinate descent.

Main Results:

  • Projected gradients and coordinate descent methods showed up to 24x faster convergence than multiplicative updates.
  • Alternating least squares performed well on sparse data but struggled with dense datasets.
  • Coordinate descent NMTF demonstrated up to 16x faster convergence than established methods.

Conclusions:

  • Projected gradients and coordinate descent are superior optimization strategies for NMTF.
  • These methods offer significant speed and potential robustness advantages over traditional multiplicative updates.