Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Competition02:34

Competition

24.4K
When organisms require the same limited resources within an environment, they may have to compete for them. Competition is a net-negative interaction. Even if two competing individuals or populations do not interact directly, the overall fitness of both competitors is lowered as a result of not having full access to the limited resource.
24.4K
The Stanford Prison Experiment03:20

The Stanford Prison Experiment

24.6K
The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
24.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

B7-H3 membranous expression correlates with histological grading in a two-center cohort of 133 pre-treatment bone and soft tissue sarcoma samples.

BMC cancer·2026
Same author

Whole-genome doubling drives immune evasion by silencing antigen presentation.

Cancer cell·2026
Same author

Darizmetinib (HRX215): A Promising 1st-in-Class Liver Regenerating Drug in Phase 1b/2a Clinical Development, Targeting the Stress Signaling Protein Kinase MKK4.

Journal of medicinal chemistry·2026
Same author

Author Correction: Titration of RAS alters senescent state and influences tumour initiation.

Nature·2026
Same author

Author Correction: A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

Nature cell biology·2026
Same author

Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression.

Cancer cell·2026

Related Experiment Video

Updated: Jan 23, 2026

Visualization of the Interstitial Cells of Cajal ICC Network in Mice
09:45

Visualization of the Interstitial Cells of Cajal ICC Network in Mice

Published on: July 27, 2011

55.4K

The Worst from Both Worlds: cHCC-ICC.

Marco Seehawer1, Luana D'Artista1, Lars Zender2

  • 1Department of Medical Oncology & Pneumology, University Hospital Tübingen, 72076 Tübingen, Germany.

Cancer Cell
|June 12, 2019
PubMed
Summary

Combined hepatocellular carcinoma-intrahepatic cholangiocarcinoma (cHCC-ICC) has a poor prognosis. New research investigates the clonal development and treatment strategies for this rare primary liver cancer.

More Related Videos

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
09:34

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Published on: January 7, 2019

9.7K
Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing
14:13

Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing

Published on: May 6, 2014

18.7K

Related Experiment Videos

Last Updated: Jan 23, 2026

Visualization of the Interstitial Cells of Cajal ICC Network in Mice
09:45

Visualization of the Interstitial Cells of Cajal ICC Network in Mice

Published on: July 27, 2011

55.4K
Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
09:34

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Published on: January 7, 2019

9.7K
Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing
14:13

Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing

Published on: May 6, 2014

18.7K

Area of Science:

  • Hepatobiliary cancers
  • Gastroenterology
  • Oncology

Background:

  • Combined hepatocellular carcinoma-intrahepatic cholangiocarcinoma (cHCC-ICC) is a rare primary liver cancer with dismal prognosis.
  • The clonal origin and optimal treatment strategies for cHCC-ICC remain unclear.

Purpose of the Study:

  • To investigate the clonal development of cHCC-ICC.
  • To provide insights into potential treatment strategies for cHCC-ICC.

Main Methods:

  • Analysis of tumor histopathology (hepatocellular carcinoma and intrahepatic cholangiocarcinoma components).
  • Genomic and molecular profiling of cHCC-ICC tumors.
  • Comparative analysis with pure hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Main Results:

  • Evidence supporting clonal development in cHCC-ICC.
  • Identification of distinct molecular features differentiating cHCC-ICC from pure HCC and ICC.
  • Insights into the cellular origins and evolutionary pathways of cHCC-ICC.

Conclusions:

  • cHCC-ICC likely arises from a common progenitor cell, exhibiting clonal expansion.
  • Understanding the molecular landscape of cHCC-ICC is crucial for developing targeted therapies.
  • This study provides a foundation for future clinical investigations and treatment paradigms for cHCC-ICC.