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Fatty Acids Corrupt Neutrophils in Cancer

Max D Wellenstein1, Karin E de Visser1

  • 1Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Cancer Cell
|June 12, 2019
PubMed

Insights

Fatty acid transport protein 2 (FATP2) on neutrophils helps tumors evade immune attack. Targeting FATP2 may unleash anti-tumor immunity and enhance cancer therapies.

Area of Science:

  • Immunology
  • Cancer Biology
  • Molecular Oncology

Background:

  • Tumor cells can evade immune surveillance through various mechanisms.
  • Neutrophils play a complex role in cancer immunity, with both pro- and anti-tumor functions.
  • Identifying specific molecular pathways that mediate tumor immune evasion is crucial for therapeutic development.

Purpose of the Study:

  • To investigate the role of fatty acid transport protein 2 (FATP2) in mediating neutrophil-driven immunosuppression in the tumor microenvironment.
  • To determine if targeting FATP2 can restore anti-tumor immunity.

Main Methods:

  • Utilized mouse models of cancer.
  • Performed molecular and cellular analyses of neutrophils and tumor cells.
  • Investigated the impact of FATP2 expression on immune cell function within the tumor microenvironment.

Main Results:

  • Demonstrated that FATP2 expression in neutrophils confers immunosuppressive properties.
  • Showed that FATP2-expressing neutrophils promote tumor growth by suppressing anti-tumor immune responses.
  • Identified FATP2 as a key mediator of tumor immune escape.

Conclusions:

  • Fatty acid transport protein 2 (FATP2) is a critical factor in neutrophil-mediated tumor immune evasion.
  • Targeting FATP2 presents a potential therapeutic strategy to enhance anti-tumor immunity.
  • FATP2 inhibition may potentiate the efficacy of immune checkpoint blockade therapies.

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