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Red blood cell distribution width as long-term prognostic markers in patients with coronary artery disease undergoing
Ting-Ting Wu1, Ying-Ying Zheng2, Xian-Geng Hou1
1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, People's Republic of China.
Insights
Red blood cell distribution width (RDW) predicts cardiac death in patients with coronary artery disease after percutaneous coronary intervention (PCI). Higher RDW levels indicate a significantly increased risk of cardiac mortality post-PCI.
Area of Science:
- Cardiology
- Hematology
- Clinical Medicine
Background:
- Coronary Artery Disease (CAD) is a leading cause of mortality worldwide.
- Percutaneous Coronary Intervention (PCI) is a common revascularization strategy for CAD.
- Prognostic markers are crucial for risk stratification in post-PCI patients.
Purpose of the Study:
- To evaluate the prognostic significance of Red Blood Cell Distribution Width (RDW) in patients with CAD.
- To determine if RDW can predict long-term outcomes after PCI.
Main Methods:
- Retrospective cohort study of 6050 patients undergoing PCI (January 2008 - December 2016).
- Patients were categorized into high (≥13.1%) and low (<13.1%) RDW groups.
- Primary outcome: long-term mortality post-PCI; follow-up averaged 35.9 months.
Main Results:
- RDW was identified as an independent predictor of cardiac death (HR 1.331, P=0.043).
- Patients with high RDW showed an increased risk of cardiac death.
- No significant differences were observed in overall long-term mortality, MACCE, MACE, stroke, bleeding, or readmission rates.
Conclusions:
- Baseline RDW is a valuable independent predictor of cardiac death in CAD patients post-PCI.
- RDW may aid in identifying patients at higher risk for cardiac-specific mortality after PCI.
Background:
The aim of this study was to assess the prognostic value of red blood cell distribution width (RDW) in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI).
Methods:
A retrospective cohort study (CORFCHD-PCI, [Identifier: ChiCTR-INR-16010153]) of 6050 patients who were hospitalized with a diagnosis of coronary artery disease (CAD) and treated with PCI from January 2008 to December 2016 were enrolled in the study. The primary outcome was long-term mortality after PCI. Clinical follow-up data of participating patients were obtained during an outpatient examination 35.9 ± 22.6 months after PCI. Demographic and clinical data and admission laboratory parameters were recorded, and patients were categorized into two groups according to RDW level (high group ≥13.1%; low group < 13.1%).
Results:
Multivariate Cox regression analysis revealed RDW as an independent prognosis factor for cardiac death. The incidence of cardiac death increased 1.33 times in patients in the high RDW group (HR, 1.331; 95% CI, 1.009-1.755, P = 0.043). Kaplan-Meier survival analysis suggested that patients with high RDW tended to have an increased accumulated risk of cardiac death. However, we did not found significant differences in the incidence of long-term mortality (adjusted HR = 1.203[0.941-1.537], P = 0.140), MACCE (adjusted HR = 1.128[0.979-1.301], P = 0.096), MACE (adjusted HR = 1.155[0.994-1.341], P = 0.059), stroke, bleeding events or readmission between the two groups.
Conclusion:
The baseline level of RDW is an independent predictor for cardiac death in post-PCI CAD patients.
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