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Updated: Jan 23, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma
Paul G Murray1,2, Lawrence S Young3
1Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Abstract:
Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors that are consistently EBV genome positive (eg, nasopharyngeal carcinoma, endemic Burkitt lymphoma), this is not the case for classical Hodgkin lymphoma (cHL), a tumor with only a variable EBV association. In light of recent developments in immunotherapeutics and small molecules targeting EBV, we believe it is now timely to reevaluate the role of EBV in cHL pathogenesis.
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