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[Biochemical cartilage imaging-update 2019].

S Trattnig1, M Raudner2, M Schreiner3

  • 1Exzellenzzentrum für Hochfeld MR, Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Lazarettgasse 14, 1090, Wien, Österreich. Siegfried.Trattnig@akhwien.at.

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Summary
This summary is machine-generated.

Advanced biochemical MRI techniques enable early, quantitative detection of cartilage damage, crucial for treatment planning and monitoring repair. These methods offer predictive insights beyond conventional imaging.

Keywords:
ArthritisContrast mediaGlycosaminoglycanKnee jointMagnetic resonance imaging

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Area of Science:

  • Biomedical Imaging
  • Radiology
  • Orthopedics

Background:

  • Magnetic Resonance Imaging (MRI) is vital for early cartilage damage detection.
  • Biochemical MR methods are essential for accurate cartilage assessment and treatment planning.

Purpose of the Study:

  • To review advanced cartilage imaging using biochemical MR techniques.
  • To present clinical applications and benefits over conventional MRI.

Main Methods:

  • Literature search of PubMed for biochemical and morphological MR imaging studies.
  • Focus on clinical applications of various biochemical MR methods.

Main Results:

  • T2 mapping is clinically feasible; T1rho is more demanding.
  • dGEMRIC use is restricted due to gadolinium concerns.
  • Sodium imaging is sensitive to glycosaminoglycans but field-strength limited.
  • Biochemical MRI detects degeneration before morphological changes and offers predictive markers.

Conclusions:

  • Biochemical MRI shifts cartilage imaging from qualitative to quantitative.
  • It is crucial for early diagnosis, monitoring disease-modifying drugs, and as a predictive biomarker.
  • Biochemical MRI assesses cartilage repair surgery efficacy for hyaline-like cartilage development.