Related Experiment Video
Updated: Jan 20, 2026
Intrathecal Delivery of Viruses in a Mouse Model for Treating Central Nervous System Diseases
Published on: June 16, 2025
Primary central nervous system lymphoma: A curable disease
1Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
Primary central nervous system lymphoma is a rare subtype of non-Hodgkin lymphoma that is confined to the brain, leptomeninges, or the eye and is associated with a relatively poor prognosis compared to other extranodal diffuse large B-cell lymphomas. However, methotrexate-based induction chemotherapy followed by consolidative chemotherapy or high-dose therapy and autologous stem cell transplantation is associated with improved survival and reduced neurotoxicity. Aberrant activation of B-cell receptor signaling and activation of nuclear factor kappa beta is a frequent genetic alteration and offers opportunities for targeted therapies in this lymphoma subtype.
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