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Updated: Jan 23, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis of 1,1,2-trisubstituted cyclopropane nucleosides in enantiomerically pure forms
Daichi Fushihara1,2, Hayato Fukuda1, Hiroshi Abe2
1Faculty of Pharmaceutical Sciences, Center for Research and Education on Drug Discovery, Hokkaido University , Sapporo , Japan.
Abstract:
Due to the unique rigid and small steric feature of cyclopropane, cyclopropane nucleosides (CPNs) in which the ribose (deoxyribose) of nucleosides are replaced by a hydroxy-substituted cyclopropane, are of great biological interest. Novel 1,1,2-trisubstituted cyclopropane nucleosides were synthesized in enantiomerically pure forms as potential antiviral agents. In the synthesis, two cyclopropane tosylates, which were prepared from chiral cyclopropane lactones previously reported by us, were used effectively as common intermediates for the CPNs. These CPNs are also potentially useful as nucleoside units to incorporate into oligonucleotides in nucleic acids chemotherapy studies.
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