Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hydrogen Bonds00:26

Hydrogen Bonds

131.8K
Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
131.8K
Hydrogen Bonds01:04

Hydrogen Bonds

13.5K
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
13.5K
Autoxidation of Ethers to Peroxides and Hydroperoxides02:23

Autoxidation of Ethers to Peroxides and Hydroperoxides

9.5K
Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.
9.5K
Regioselectivity of Electrophilic Additions-Peroxide Effect02:35

Regioselectivity of Electrophilic Additions-Peroxide Effect

10.4K
In the presence of organic peroxides, the addition of hydrogen bromide to an alkene yields the isomer that is not predicted by Markovnikov’s rule. For example, the addition of hydrogen bromide to 2-methylpropene in the presence of peroxides gives 1-bromo-2-methylpropane. This addition reaction proceeds via a free radical mechanism, which reverses the regioselectivity. The free radical reaction mechanism involves three stages: initiation, propagation, and termination.
10.4K
Aggregates Classification01:29

Aggregates Classification

981
Aggregate classification is generally based on its size, petrographic characteristics, weight, and source. Size classification ranges from coarse to fine aggregates, defined by the size of the particles. Coarse aggregates are particles that do not pass through ASTM sieve No. 4, and aggregates that pass through the sieve are fine aggregates.
Petrographic classification groups aggregates based on common mineralogical characteristics. Some of the common mineral groups found in aggregates are...
981
Introduction to Membrane Proteins01:16

Introduction to Membrane Proteins

80.8K
The cell membrane, or plasma membrane, is an ever-changing landscape. It is described as a fluid mosaic where various macromolecules are embedded in the phospholipid bilayer. Among the macromolecules are proteins. The protein content varies across cell types. For example, mitochondrial inner membranes contain ~76% protein content, while myelin contains ~18% protein content. Individual cells contain many types of membrane proteins—red blood cells contain over 50—and different cell...
80.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic Impact of Peripheral Expression of Mutant Huntingtin in <i>C. elegans</i>.

Journal of proteome research·2026
Same author

Toward Metabolomics Analyses With Combined Capillary Vibrating Sharp-Edge Spray Ionization and Atmospheric Pressure Chemical Ionization.

Rapid communications in mass spectrometry : RCM·2026
Same author

Structural Characterization of Calcium-Dependent Calmodulin-Calmidazolium Binding using Capillary Vibrating Sharp-Edge Spray-based Native Mass Spectrometry and In-Droplet Hydrogen Deuterium Exchange Mass Spectrometry.

bioRxiv : the preprint server for biology·2026
Same author

Integrating Simple Microfluidics Design/Fabrication with a Novel Ionization Source for Time-Resolved Chemical Reaction Studies by Mass Spectrometry.

ACS omega·2026
Same author

Nitric Oxide Insertion into a Metalloporphyrin-Carbon Bond.

JACS Au·2026
Same author

Optimized Photoemission from Organic Molecules in 2D Layered Halide Perovskites.

Journal of the American Chemical Society·2026

Related Experiment Video

Updated: Jan 23, 2026

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
08:57

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases

Published on: February 24, 2018

10.5K

Hydrogen Peroxide Modifies Aβ-Membrane Interactions with Implications for Aβ40 Aggregation.

Albert W Pilkington1, Gregory C Donohoe1, Novruz G Akhmedov1

  • 1The C. Eugene Bennett Department of Chemistry , West Virginia University , 217 Clark Hall , Morgantown , West Virginia 26506 , United States.

Biochemistry
|June 13, 2019
PubMed
Summary
This summary is machine-generated.

Hydrogen peroxide (H2O2) impacts beta-amyloid (Aβ) aggregation, especially near lipid membranes. This study reveals H2O2 primarily causes lipid peroxidation, reducing Aβ

More Related Videos

Hydrogen Production and Utilization in a Membrane Reactor
10:00

Hydrogen Production and Utilization in a Membrane Reactor

Published on: March 10, 2023

3.2K
Author Spotlight: Design and Evaluation of Au-Electroplated Carbon Fiber Cloth Electrodes for Hydrogen Peroxide Fuel Cells
06:39

Author Spotlight: Design and Evaluation of Au-Electroplated Carbon Fiber Cloth Electrodes for Hydrogen Peroxide Fuel Cells

Published on: October 20, 2023

3.8K

Related Experiment Videos

Last Updated: Jan 23, 2026

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
08:57

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases

Published on: February 24, 2018

10.5K
Hydrogen Production and Utilization in a Membrane Reactor
10:00

Hydrogen Production and Utilization in a Membrane Reactor

Published on: March 10, 2023

3.2K
Author Spotlight: Design and Evaluation of Au-Electroplated Carbon Fiber Cloth Electrodes for Hydrogen Peroxide Fuel Cells
06:39

Author Spotlight: Design and Evaluation of Au-Electroplated Carbon Fiber Cloth Electrodes for Hydrogen Peroxide Fuel Cells

Published on: October 20, 2023

3.8K

Area of Science:

  • Neuroscience
  • Biochemistry
  • Oxidative Stress

Background:

  • Alzheimer's disease (AD) involves beta-amyloid (Aβ) plaque formation in the brain.
  • Aβ aggregation into various species is linked to neurotoxicity.
  • Oxidative damage, including hydrogen peroxide (H2O2) spikes, is implicated in neurodegenerative diseases.

Purpose of the Study:

  • To investigate the effect of environmental H2O2 on Aβ aggregation.
  • To examine the role of lipid membranes in H2O2-mediated Aβ aggregation.
  • To understand the mechanisms behind H2O2's impact on Aβ-membrane interactions.

Main Methods:

  • Exposing Aβ40 to varying concentrations of H2O2.
  • Utilizing lipid extract vesicles to mimic brain membranes.
  • Analyzing Aβ aggregation kinetics and fibril morphology.
  • Assessing Aβ-vesicle interactions and lipid peroxidation.

Main Results:

  • H2O2 selectively oxidized methionine 35 in Aβ40 (Aβ40Met35[O]).
  • Oxidation mildly reduced Aβ aggregation rate and altered fibril morphology at high H2O2 levels.
  • H2O2 significantly impacted Aβ aggregation in the presence of lipids, reducing Aβ affinity for vesicles.
  • This reduced affinity was mainly due to lipid peroxidation, not Aβ oxidation.

Conclusions:

  • Environmental H2O2 influences Aβ aggregation, with a more significant effect in the presence of lipid membranes.
  • Lipid peroxidation, induced by H2O2, plays a key role in modulating Aβ-membrane interactions.
  • Findings highlight the complex interplay between oxidative stress, lipids, and Aβ pathology in Alzheimer's disease.