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Semen Quality and Ferritin and Transferrin Seminal Levels

Gilmar Pereira Silva1, Vítor Pereira Xavier Grangeiro2, Fabiana Pirani Carneiro1

  • 1Department of Medicine, University of Brasilia, Brazil.

Folia Medica
|June 13, 2019
PubMed

Insights

Seminal quality in chronic hemodialysis patients is linked to seminal transferrin levels, not seminal ferritin. This finding aids in evaluating potential subfertility in these patients.

Area of Science:

  • Nephrology
  • Reproductive Medicine
  • Clinical Biochemistry

Background:

  • Chronic hemodialysis (CH) patients may experience altered seminal quality.
  • Investigating the relationship between seminal parameters and specific proteins like ferritin and transferrin is crucial.

Purpose of the Study:

  • To explore the association between seminal quality and seminal levels of ferritin and transferrin in men undergoing chronic hemodialysis.
  • To determine if seminal ferritin or transferrin levels are indicative of subfertility in CH patients.

Main Methods:

  • A cross-sectional study comparing 60 men on CH with 30 healthy controls (age 18-60).
  • Semen analysis (spermogram) and measurement of seminal ferritin and transferrin levels were performed.
  • Participants were screened for infection/inflammation and eugonadism.

Main Results:

  • Men undergoing CH showed significantly lower seminal parameters and seminal transferrin levels compared to controls.
  • Seminal ferritin levels were similar between CH patients and controls.
  • Seminal transferrin levels, but not seminal ferritin, were significantly associated with seminal parameters (p<0.001).

Conclusions:

  • Seminal quality in chronic hemodialysis patients is associated with seminal transferrin levels.
  • Seminal ferritin levels do not appear to be related to seminal quality in this cohort.
  • Measuring seminal transferrin may be useful for initial evaluation of subfertility in CH patients.
Abstract

Keywords:
chronic kidney diseasemale infertilityseminal ferritinseminal qualityseminal transferrin

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