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Elevated homocysteine as an independent risk for intracranial atherosclerotic stenosis

Ying Liu1, Jing-Hui Song1, Xiao-He Hou2

  • 1Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Aging
|June 13, 2019
PubMed

Insights

Elevated homocysteine levels are linked to intracranial atherosclerotic stenosis (ICAS). Higher homocysteine concentrations increase the risk of ICAS in both stroke patients and healthy individuals.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Biochemistry

Background:

  • Intracranial atherosclerotic stenosis (ICAS) is a significant cause of ischemic stroke.
  • Homocysteine is an amino acid implicated in vascular disease.
  • The relationship between homocysteine and ICAS requires further elucidation.

Purpose of the Study:

  • To investigate the association between homocysteine concentration and the presence of ICAS.
  • To determine if homocysteine is an independent risk factor for ICAS.

Main Methods:

  • Magnetic resonance angiography (MRA) was used to assess ICAS in 933 acute ischemic stroke patients and 798 non-stroke controls.
  • Homocysteine concentrations were measured in all participants.
  • Logistic regression analyses were performed to evaluate the association between homocysteine levels and ICAS.

Main Results:

  • Participants with ICAS had significantly higher homocysteine concentrations than those without ICAS.
  • Increased homocysteine concentration was significantly associated with ICAS in both patients (OR: 1.04) and controls (OR: 1.10) per 1 μmol/L increment.
  • Higher quartiles of homocysteine were independent predictors of ICAS in both patient and control groups.

Conclusions:

  • Elevated homocysteine concentration is an independent risk factor for intracranial atherosclerotic stenosis.
  • Homocysteine may play a crucial role in the development of ICAS.
  • Monitoring homocysteine levels could be important for assessing ICAS risk.

Keywords:
acute ischemic strokeatherosclerosishomocysteineintracranial atherosclerotic stenosismagnetic resonance angiography

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