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A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors
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A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

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Neurotoxins.

Adrian A Ong1, David A Sherris1

  • 1Department of Otolaryngology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York.

Facial Plastic Surgery : FPS
|June 13, 2019
PubMed
Summary
This summary is machine-generated.

Botulinum toxin is widely used in facial plastic surgery for aesthetic and functional improvements. This review covers its applications, including treating wrinkles and other conditions, with dosage guidelines for onabotulinumtoxinA.

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Area of Science:

  • Plastic Surgery
  • Dermatology
  • Aesthetic Medicine

Background:

  • Botulinum toxin, approved in 2002 for glabellar rhytids, has expanded its use in facial plastic surgery.
  • Numerous off-label applications have been established, demonstrating safety and efficacy.
  • Various formulations of botulinum toxin are available.

Purpose of the Study:

  • To review the aesthetic and functional applications of botulinum toxin in facial plastic and reconstructive surgery.
  • To provide an overview of current clinical uses beyond its initial FDA approval.
  • To discuss recommended unit dosages for specific injection sites using onabotulinumtoxinA.

Main Methods:

  • Literature review of studies on botulinum toxin in facial plastic surgery.
  • Analysis of clinical applications for both aesthetic and functional purposes.
  • Compilation of dosage recommendations based on onabotulinumtoxinA.

Main Results:

  • Botulinum toxin effectively manages various facial rhytids, brow ptosis, gingival display, masseteric hypertrophy, platysmal bands, and nerve paralysis.
  • It is also used for hypertrophic scars and keloids.
  • Established safety and efficacy across diverse applications.

Conclusions:

  • Botulinum toxin is a versatile tool in facial plastic surgery with established safety and efficacy.
  • Its applications extend beyond primary indications to address a range of aesthetic and functional concerns.
  • Guidance on unit dosage, specifically for onabotulinumtoxinA, is provided to aid practitioners.