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Prognostic Significance of Phosphorylated Fyn in Patients with Lung Adenocarcinoma after Lung Resection

Shigeto Nishikawa1, Toshi Menju1, Koji Takahashi1

  • 1Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
|June 14, 2019
PubMed
Abstract

Insights

Phosphorylated Fyn (pFyn) expression is linked to poorer outcomes in lung adenocarcinoma patients. This finding suggests pFyn may be a prognostic marker for lung cancer survival.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Src family tyrosine kinases, including Fyn, are implicated in cancer progression.
  • Fyn is a known effector of epidermal growth factor receptor (EGFR) signaling and a potential therapeutic target.
  • The prognostic value of phosphorylated Fyn (pFyn) in lung adenocarcinoma remains largely unexplored.

Purpose of the Study:

  • To investigate the prognostic significance of pFyn expression in lung adenocarcinoma.
  • To determine the association between pFyn status and patient survival outcomes.

Main Methods:

  • Analysis of 282 lung adenocarcinoma specimens using tissue microarrays.
  • Immunohistochemical assessment of pFyn expression, classifying cases as positive or negative.
  • Statistical analysis correlating pFyn expression with clinical parameters and survival data.

Main Results:

  • pFyn expression was detected in 107 out of 282 cases.
  • pFyn positivity significantly correlated with male gender, p53 mutations, advanced pathological stage, larger tumor size, and increased invasion (plural, lymphatic, vascular).
  • pFyn positivity was associated with significantly poorer relapse-free survival (RFS) and overall survival (OS).

Conclusions:

  • Phosphorylated Fyn (pFyn) expression is a significant prognostic indicator in lung adenocarcinoma.
  • pFyn may influence patient prognosis following surgical resection for lung adenocarcinoma.
Keywords:
immunohistochemistrylung adenocarcinomaphosphorylated Fynsurvival analysis

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