Related Experiment Video
Updated: Jan 23, 2026

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
[PD-L1-Mediated Immune Escape Mechanism of Cancer Stem-Like Cells]
Masahiro Matsuki1, Yoshihiko Hirohashi, Toshihiko Torigoe
1Dept. of Pathology, Sapporo Medical University School of Medicine.
Abstract:
Immune checkpoint inhibitors(ICIs)have provided great success in cancer treatment field, and immunotherapies using ICIs have become standard therapy for several cancers. Cancer stem-like cells(CSCs)are defined by their higher tumorigenicity and resistance to chemotherapy and radiotherapy, thus they are supposed to be responsible for recurrence and distant metastasis. Therefore, control of CSCs is a key factor to improve patients' prognosis. In this review article, we summarize the expression of PD-L1, a molecular target of ICIs, in CSCs, and discuss the possibility of CSC-targeting immunotherapy using ICIs.
Related Concept Videos
Cell-mediated Immune Responses
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Escape Velocity
To calculate the escape velocity, it is assumed that no energy is lost to any frictional forces. In practice, a satellite...
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

