[Hyperthermic intraperitoneal chemotherapy].

Area of Science:

• Oncology
• Surgical Oncology
• Chemotherapy

Background:

• Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are established treatments for select peritoneal malignancies.
• Achieving complete macroscopic cytoreduction is critical for successful multimodal treatment outcomes.
• The precise role and benefit of intraperitoneal chemotherapy remain subjects of ongoing discussion.

Purpose of the Study:

• To elucidate the fundamental principles of hyperthermic intraperitoneal chemotherapy (HIPEC).
• To evaluate the significance and value of HIPEC as part of a comprehensive multimodal treatment strategy for peritoneal malignancies.

Main Methods:

• This is a review article, synthesizing existing knowledge and literature.
• Focus is on explaining the theoretical underpinnings and clinical rationale for HIPEC.
• Analysis of HIPEC's contribution within the context of multimodal cancer therapy.

Main Results:

• Cytoreductive surgery (CRS) aims for complete removal of visible tumors.
• Hyperthermic intraperitoneal chemotherapy (HIPEC) delivers heated chemotherapy directly into the peritoneal cavity.
• The combination of CRS and HIPEC is considered a standard of care for specific patient groups.

Conclusions:

• Complete macroscopic cytoreduction is a prerequisite for effective multimodal treatment.
• This review underscores the importance of understanding HIPEC's principles.
• The value of HIPEC within the multimodal treatment paradigm for peritoneal malignancies is highlighted.