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Updated: Jan 23, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
The prognostic nutritional index in resected high-grade pulmonary neuroendocrine carcinoma
Masayuki Okui1, Hirotoshi Horio2, Ayaka Asakawa2
1Department of Thoracic Surgery, Hiratsuka City Hospital, 1-19-1 Minamihara, Hiratsuka, Kanagawa, 254-0065, Japan. jersey0719@yahoo.co.jp.
Objective:
The prognostic nutritional index is a potential predictive indicator in other cancers and can be easily determined at low cost. To identify useful prognostic markers for high-grade neuroendocrine carcinomas, we examined the prognostic significance of the prognostic nutritional index in patients with resected high-grade pulmonary neuroendocrine carcinoma.
Methods:
We retrospectively reviewed perioperative clinical and laboratory data of patients who underwent pulmonary resection for high-grade neuroendocrine carcinoma between January 2000 and December 2014. Associations between the preoperative prognostic nutritional index and the patients' clinicopathological characteristics were analyzed to determine its prognostic significance.
Results:
The study comprised 61 patients, the majority of whom were men (85%). The median age was 70.0 years, and the median follow-up period was 42 months. No significant differences in the clinicopathological characteristics were observed between the high and low prognostic nutritional index groups. The 5-year overall survival and recurrence-free survival times were significantly shorter in the low prognostic nutritional index group than in the high prognostic nutritional index group (78.8% vs. 51.4% and 71.7% vs. 34.5%, respectively; p < 0.05). The prognostic nutritional index was confirmed as an independent prognostic factor (hazard ratio: 2.419, 95.0% confidence interval: 1.044-5.606; p < 0.05). A significantly greater proportion of patients developed distant metastases in the low prognostic nutritional index group than in the high prognostic nutritional index group (p < 0.05).
Conclusion:
A low prognostic nutritional index is associated with poor survival in patients with resected high-grade pulmonary neuroendocrine carcinoma.
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