Arterial embolism in a patient with pulmonary embolism and patent foramen ovale
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Updated: Jan 23, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
Waiel Abusnina1, Mohammed Megri2, Basel Edris3
1Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall UniversityHuntingtonWest Virginia.
Abstract:
Paradoxical embolization is an uncommon but devastating complication of pulmonary embolism and continues to be frequently missed. Although the prevalence of patent foramen ovale is 25% to 30%, the risk of paradoxical embolism is <2% of all arterial ischemia. Paradoxical embolism is infrequent but can involve almost any artery of the body. Here, we present a case of a 65-year-old woman with paradoxical systemic arterial embolism secondary to deep venous thrombosis and pulmonary embolism in the presence of patent foramen ovale. High suspicion for paradoxical embolism is needed in the event of unexplained arterial occlusion. Awareness of this complication with prompt recognition and treatment could serve to preclude significant disability and death.
Insights
Paradoxical embolism, a rare complication of pulmonary embolism, can cause arterial occlusion. Prompt recognition in patients with a patent foramen ovale is crucial to prevent severe outcomes.
Area of Science:
- Cardiology
- Vascular Surgery
- Internal Medicine
Background:
- Paradoxical embolism is an uncommon yet severe complication of pulmonary embolism (PE).
- Patent foramen ovale (PFO) is present in 25-30% of the population, but the risk of paradoxical embolism is low (<2% of arterial ischemia).
Observation:
- A case of a 65-year-old woman presented with paradoxical systemic arterial embolism.
- The embolism was secondary to deep venous thrombosis (DVT) and PE, with an underlying PFO.
Findings:
- Unexplained arterial occlusion warrants high suspicion for paradoxical embolism.
- This condition can affect nearly any artery in the body.
Implications:
- Increased awareness and prompt diagnosis of paradoxical embolism are vital.
- Timely treatment can prevent significant patient disability and mortality.
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