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Susceptibility Assessment of Methicillin-Resistant Staphylococcus aureus Strains to Lepidium sativum Extract

Amna A Saddiq1, Azza M Mohamed2,3

  • 1Biology Department, Faculty of Science-Al Faisaliah, King Abdulaziz University, Jeddah, Saudi Arabia.

Dose-Response : a Publication of International Hormesis Society
|June 14, 2019
PubMed

Insights

Lepidium sativum seed extract shows antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains. This plant extract effectively reduced bacterial biomass and inhibited MRSA growth in vitro.

Area of Science:

  • Microbiology
  • Pharmacognosy
  • Natural Product Chemistry

Background:

  • * Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat due to widespread antibiotic resistance.
  • * Plant-derived compounds are a potential source for novel antimicrobial agents.
  • * Lepidium sativum (garden cress) has traditional uses, but its efficacy against MRSA requires scientific validation.

Purpose of the Study:

  • * To investigate the in vitro antimicrobial susceptibility of six MRSA strains to aqueous Lepidium sativum seed extract.
  • * To evaluate the impact of varying extract concentrations on bacterial growth and inhibition.
  • * To explore the potential of L. sativum as a natural therapeutic agent against MRSA infections.

Main Methods:

  • * Six strains of MRSA were exposed to aqueous L. sativum seed extract at concentrations ranging from 5 to 20 mg/mL.
  • * Bacterial growth was assessed by measuring microbial biomass over 24 and 48-hour periods.
  • * Antimicrobial activity was quantified by measuring the inhibition zone (IZ) and visualized using scanning electron microscopy.

Main Results:

  • * L. sativum seed extract significantly reduced MRSA biomass at concentrations of 15 and 20 mg/mL after 24 or 48 hours.
  • * The highest inhibition zone (IZ) was observed for the MRSA strain LN871241 at a 20 mg/mL extract concentration.
  • * Scanning electron microscopy confirmed the antimicrobial effects of the extract on MRSA morphology.

Conclusions:

  • * Aqueous extract of Lepidium sativum seeds exhibits significant in vitro antimicrobial activity against MRSA.
  • * L. sativum extract demonstrates potential as a natural therapeutic candidate for treating MRSA infections.
  • * Further research is warranted to isolate active compounds and elucidate the mechanism of action.
Keywords:
Lepidium sativumantibacterialmethicillin-resistant S aureusmicrobial biomass

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