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Nucleoside Analogues as Antibacterial Agents.

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Frontiers in Microbiology
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PubMed
Summary

Repurposing nucleoside analogues, approved for viral and cancer treatments, shows promise for combating antibiotic-resistant bacteria. This approach offers a faster, cost-effective alternative to developing new antibacterial drugs.

Keywords:
antibacterial agentsantibiotic resistanceantimicrobialmultidrug-resistant bacteriapurine analoguespyrimidine analoguesrepurposed antibiotics

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Area of Science:

  • Microbiology
  • Drug Discovery
  • Infectious Diseases

Background:

  • Rising antibiotic resistance necessitates novel therapeutic strategies.
  • Repurposing existing drugs offers a faster, more cost-effective alternative to de novo drug development.
  • Nucleoside analogues, widely used in antiviral, antifungal, and cancer therapies, are under-explored for bacterial infections.

Purpose of the Study:

  • To review the antibacterial potential of clinically approved nucleoside analogues.
  • To explore their mechanisms of action and antibacterial activities.
  • To consider limitations for their repurposing in treating bacterial infections.

Main Methods:

  • Literature review of studies on nucleoside analogues with antibacterial activity.
  • Analysis of mechanisms of action for pyrimidine and purine derivatives.
  • Evaluation of antibacterial efficacy and potential limitations.

Main Results:

  • Numerous clinically approved nucleoside analogues, including halogenated, thiolated, and azolated derivatives, exhibit antibacterial activity.
  • Existing studies indicate promising results for these compounds in treating bacterial infections.
  • A significant number of nucleoside analogues have demonstrated antibacterial properties.

Conclusions:

  • Nucleoside analogues represent a promising class of compounds for repurposing against bacterial infections.
  • Further research into their mechanisms and clinical application is warranted.
  • Repurposing nucleoside analogues could expedite the development of new treatments for challenging bacterial infections.