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Related Experiment Videos

Decrease of brain extracellular fluid [Na] and its interaction with other factors influencing sodium appetite in

R S Weisinger1, D A Denton, M J McKinley

  • 1Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Vic., Australia.

Brain Research
|September 8, 1987
PubMed
Summary

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Lowering cerebrospinal fluid (CSF) sodium concentration significantly stimulates salt appetite in sheep. This effect is sustained and can be reduced by angiotensin II.

Area of Science:

  • Neuroscience
  • Physiology
  • Animal Behavior

Background:

  • Previous studies in sheep demonstrated that increased cerebrospinal fluid (CSF) sodium ([Na]) reduces sodium appetite.
  • Conversely, increased CSF osmotic pressure, leading to lower CSF [Na], doubles sodium appetite.

Purpose of the Study:

  • To investigate the effect of directly lowering CSF [Na] concentration on sodium appetite.
  • To determine if this effect is sustained and if angiotensin II influences it.

Main Methods:

  • Infusion of isotonic mannitol into the CSF of sodium-deplete sheep to lower CSF [Na].
  • Administration of angiotensin II via intracerebroventricular (i.c.v.) infusion.
  • Monitoring of sodium appetite in response to these interventions.

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Main Results:

  • Simple dilution of CSF [Na] with isotonic mannitol effectively stimulated sodium appetite.
  • Lowering CSF [Na] stimulated salt appetite in both mildly and severely sodium-deplete animals.
  • The appetite-stimulating effect of decreased CSF [Na] was sustained for over 48 hours.
  • Pre-infusion of angiotensin II significantly diminished the sodium appetite response to reduced CSF [Na].

Conclusions:

  • Decreasing CSF [Na] concentration is a potent stimulus for salt appetite in sheep.
  • This effect is long-lasting and independent of the severity of sodium depletion.
  • Angiotensin II can interfere with the salt appetite stimulation caused by reduced CSF [Na].