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Radionuclide Imaging of Atherothrombotic Diseases

Mitchel R Stacy1,2

  • 1Department of Surgery, The Ohio State University College of Medicine, Columbus, OH.

Current Cardiovascular Imaging Reports
|June 14, 2019
PubMed
Abstract

Insights

Radionuclide imaging using SPECT and PET offers new ways to study atherosclerosis. These techniques help visualize plaque progression and rupture, aiding in the diagnosis of atherothrombotic diseases.

Area of Science:

  • Nuclear medicine
  • Cardiovascular imaging
  • Molecular imaging

Background:

  • Atherosclerosis and vulnerable plaque are major causes of cardiovascular events.
  • Understanding plaque progression and rupture mechanisms is crucial for effective treatment.

Purpose of the Study:

  • To review recent advancements in radionuclide imaging for atherosclerosis.
  • To highlight developments in preclinical and clinical applications of SPECT and PET.

Main Methods:

  • Focus on single photon emission computed tomography (SPECT) and positron emission tomography (PET).
  • Exploration of various molecular targets and imaging approaches.
  • Characterization of physiological processes in plaque evolution.

Main Results:

  • SPECT and PET can target key plaque processes like inflammation, thrombosis, angiogenesis, and microcalcification.
  • Specific molecular markers enable sensitive, non-invasive plaque detection and characterization.
  • Ongoing evolution of imaging capabilities for atherosclerosis evaluation.

Conclusions:

  • Radionuclide imaging continues to advance for physiological assessment of atherosclerosis.
  • This review summarizes the latest developments in imaging atherothrombotic diseases.
Keywords:
PETSPECTatherosclerosisatherothrombosismolecular imagingradionuclide imaging

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