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Sensitive Skin: Lessons From Transcriptomic Studies.

Adeline Bataille1,2, Christelle Le Gall-Ianotto1,2, Emmanuelle Genin3

  • 1LIEN, F-29200, Univ Brest, Brest, France.

Frontiers in Medicine
|June 14, 2019
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Summary
This summary is machine-generated.

Sensitive skin (SS) involves unpleasant sensations due to normally harmless stimuli. Transcriptomic studies reveal gene expression differences, offering clues to SS pathophysiology and guiding future research.

Keywords:
RNAseqmicroarraypathogenic mechanismpathophysiologysensitive skintranscriptomics

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Area of Science:

  • Dermatology
  • Genomics
  • Molecular Biology

Background:

  • Sensitive skin (SS) is defined by unpleasant sensations triggered by non-noxious stimuli.
  • The underlying pathophysiology of SS, potentially involving inflammation and nerve involvement, remains poorly understood.
  • Transcriptomic analysis offers a powerful approach to investigate the molecular basis of SS.

Purpose of the Study:

  • To review and discuss existing transcriptomic studies on sensitive skin.
  • To highlight the contribution of transcriptomics to understanding SS pathophysiology.
  • To advocate for larger-scale transcriptomic studies to elucidate SS mechanisms.

Main Methods:

  • Review of two key publications utilizing transcriptomic approaches (microarray and RNA-seq) on sensitive skin (SS) and non-sensitive skin (NSS) samples.
  • Analysis of gene expression profiles, including messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs), in SS versus NSS.
  • Identification of differentially expressed genes and associated biological pathways.

Main Results:

  • Microarray analysis revealed significant differences in gene expression between SS and NSS, identifying distinct gene clusters.
  • RNA-seq identified differentially expressed mRNAs and lncRNAs in SS, providing a comprehensive molecular profile.
  • These transcriptomic findings suggest a wide range of genes and pathways implicated in the pathogenesis of SS.

Conclusions:

  • Transcriptomic studies provide valuable insights into the complex pathophysiology of sensitive skin.
  • Existing studies have identified numerous differentially expressed genes and potential pathways involved in SS.
  • Further large-scale transcriptomic research is crucial for detecting and analyzing pathogenic mechanisms in SS.